Day 1 :
Keynote Forum
William J. Rowe
Medical University of Ohio, USA
Keynote: Hypertension
Time : 09:30-10:10
Biography:
Dr.William J. Rowe M.D. is a board certified specialist in Internal Medicine. He received his M.D. at the University of Cincinnati and was in private practice in Toledo, Ohio for 34 years. He is a former Assistant Clinical Professor of Medicine at the University of Ohio, School of Medicine at Toledo. Of only 4 space syndromes, he has published 2: "The Apollo 15 Space Syndrome" and "Neil Armstrong Syndrome." He published Neil Armstrong's probable lunar acute heart failure. He has been listed in the Marquis Whos Who of the World from 2002-2009,2013, 2014, 2015, 2016.
Abstract:
Of 12 moon walkers, James Irwin on day after return from Apollo 15 mission, showed extraordinary bicycle (B) stress
test (ST) hypertension (275/125) after 3 minutes exercise; supervising > 5000 maximum treadmill ST, author never
witnessed ST- blood pressure approaching this level. Symptom-limited maximum B stress test showed “cyanotic fingernails”;
possibly venous blood trapped peripherally, supporting author’s “Apollo 15 Space Syndrome,” postulating that severe fingertip
pain during space walks, triggered by plasma fluid, trapped distally; mechanism could be related to endothelial dysfunction,
providing “silent ischemia” warning. Neil Armstrong returned to Earth with severe diastolic hypertension (160/135), consistent
with ischemic left ventricular dysfunction; 50 mm increase in comparison with resting BP 110/85. With inhalation of lunar
dust, brought into habitat on space suit, with high lunar iron, this dust inhalation, along with reduced space flight- transferrin
and antioxidant, calcium (Ca) blocker-magnesium, conducive to severe oxidative stress, Ca overload with potential endothelial
injuries. Using moon walker studies as example, begs question as to whether we can apply this limited information regarding
highly toxic lunar dust in formulating concept i.e. role of dust-laden urban pollution in contributing to hypertension; IRON
dust from brakes may be responsible..
Keynote Forum
Yaping Tian
Yaping Tian, Chinese PLA General Hospital, China
Keynote: The amino acids profile variation in dried blood spots from patients with acute coronary syndrome
Time : 11:10-11:40
Biography:
Yaping Tian, Professor of Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, Professor of Nankai University, Professor of Tsinghua University. Dr Tian received his Master Degree in Medicine from Chinese PLA Postgraduate Medical School in 1989 and PhD from Academy of Military Medical Sciences in 1993. He had been trained as Postdoctoral Fellow for 2 years(1995-1997) in The Queen Elizabeth Hospital, Australia. Dr. Tian has been focusing on the study of the specific serum proteomic profiles and genetic signatures in different diseases, especially on cancer and cardiovascular diseases. He also focused on the studies of antioxidants in herbal medicine and free radical biology. Dr. Tian has received more than 20 grants and published more than 300 scientific papers in peer-reviewed journals. He is on the editorial boards of several journals and the honor chairman of the Clinical Biochemistry and Applied Molecular Biology Association, CSBMB.
Abstract:
The cardiovascular disease (CVD), which includes acute coronary syndrome (ACS) and heart failure (HF), is the global
leading cause of human death. The blood biomarkers, as targets of treatment, will help to prevent and treat CVD. They
could aid in early prognosis and diagnosis of CVD and effectively reduce the morbidity and mortality, which is the focus in
research for CVD. This study aimed to screen effective blood markers for different stages of CVD. We have detected 11 amino
acids and SA in HC and patients with MS, ACS and HF. GLY and PRO were significant difference between the AMI and the
UAP. The ROC curve area of them in multivariate analysis was 0.681 (0.600-0.754) (p<0.001). ARG, GLY, MET, TYR and SA
were significant difference between the AMI and the MS. The ROC curve area of GLY and ARG in multivariate analysis was
0.953 (0.911-0.979) (p<0.001). There were significant differences in 9 amino acids and SA between the AMI and the HC. The
ROC curve area of GLY, ORN and PHE in multivariate analysis was 0.991 (0.962-0.999) (p<0.001). There were significant
differences in 3 parameters between the CHF and the UAP. The ROC curve area of CIT and L-I-P in multivariate analysis
was 0.839 (0.742-0.910) (p<0.001). Eleven blood amino acids and SA in patients with MS, ACS and CHF and in HC have
been analyzed and the variation between groups have been found, the results suggested that branched chain amino acids and
aromatic amino acids may be biomarkers for CVD.
Keynote Forum
Kunlun He
Chinese PLA General Hospital, China
Keynote: Kv4.3 Modulates the distribution of herg
Time : 11:40-12:10
Biography:
Kunlun He is the Vice President of Chinese PLA General Hospital and his main Research Direction is Heart Disease. He has published more than 126 papers in
reputed journals and has been serving as an Editorial Board Member of repute.
Abstract:
Kv4.3 Modulates the distribution of herg
This study examines the interaction between hERG and Kv4.3. The functional interaction between hERG and Kv4.3,
expressed in a heterologous cell line, was studied using patch clamp techniques, western blot, immunofluorescence and
co-immunoprecipitation. Co-expression of Kv4.3 with hERG increased hERG current density (tail current after a step to +10
mV: 26±3 versus 56±7 pA/pF, p<0.01). Kv4.3 co-expression also increased the protein expression and promoted the membrane
localization of hERG. Western blot showed Kv4.3 increased hERG expression by Hsp70. hERG and Kv4.3 co-localized and
co-immunoprecipitated in cultured 293T cells, indicating physical interactions between hERG and Kv4.3 proteins in vitro. In
addition, Hsp70 interacted with hERG and Kv4.3 respectively, and formed complexes with hERG and Kv4.3. The α subunit of
Ito Kv4.3 can interact with and modify the localization of the α subunit of IKr hERG, thus providing potentially novel insights
into the molecular mechanism of the malignant ventricular arrhythmia in heart failure.
Keynote Forum
Jorge A Sison
Medical Centre Manila, Philippines
Keynote: Resistant hypertension: How do i treat?
Time : 12:10-12:40
Biography:
Dr. Jorge A. Sison is had done is MD specialization in internal medicine and cardiology. He is certified Philippine College of Cardiology and Philippine College of
Physicians. He currently serves at Manila medical centre as a Cardiology specialist.
Abstract:
By definition, Resistant Hypertension (RH) is Blood Pressure (BP) that remains above 140/90 despite appropriate tripledrug
regimen including a diuretic (JNC 7) or controlled BP requiring at least 4 medications. Prevalence of RH is 10-30% in
general practice (Kaplan 2006), 12.8% in drug-treated US adults. Prevalence continues to increase. Uncontrolled BP that leads
to suspect RH can be of two types: A. Pseudo-resistance which may be due improper BP measurement, “White-coat” effect, or
poor medication adherence; B. True resistant hypertension. Self BP measurement has shown to minimize white-coat effect. In
a study by dela Sierra (Hypertension 2011) 1/3 of clinic RH is actually white-coat by ABPM. Regarding issue of adherence, in a
study by Jung (J Hypertension 2013), among 375 RH patients, analysis of urine showed only 3.5% were true RH. Confirmation
of true RH is important because controlling their BP to <140/90 has reduced morbidity and mortality (Bangalore 2014).
The causes of true RH are secondary hypertension, drug-induced, volume overload, high aldosterone levels, obesity, high
alcohol intake, sleep apnea and clinical inertia. These factors must be well investigated to achieve success in BP control. In the
management of RH, in association with lifestyle modification, three drugs to be used are Diuretics, ACE inhibitors or ARBs
and calcium antagonists. Beta-blockers should be used if there is compelling indication. Among the diuretics, chlorhalidone
has the best profile among the thiazide and thiazide-like classes. Potassium-sparing diuretics particularly spironalactone is also
efficacious in uncontrolled RH. Finally, clinical inertia is another factor that leads to uncontrolled BP, wherein, clinicians fail
to intensify therapy when indicated. The role of renal denervation (RD) is still inconclusive. Meta-analysis of 10 RCTs suggests
that RD is not superior to drug treatment.
Keynote Forum
William J Rowe
Medical University of Ohio, USA
Keynote: Neil Armstrong syndrome and thermogenesis
Time : 12:40-13:10
Biography:
Dr.William J. Rowe M.D. is a board certified specialist in Internal Medicine. He received his M.D. at the University of Cincinnati and was in private practice in Toledo,
Ohio for 34 years. He is a former Assistant Clinical Professor of Medicine at the University of Ohio, School of Medicine at Toledo. Of only 4 space syndromes, he
has published 2: "The Apollo 15 Space Syndrome" and "Neil Armstrong Syndrome." He published Neil Armstrong's probable lunar acute heart failure. He has been
listed in the Marquis Whos Who of the World from 2002-2009,2013, 2014, 2015, 2016.
Abstract:
Neil Armstrong syndrome applies both to Earth with common magnesium (Mg) deficits and with Mg deficits invariably
occurring in Space (S); this can trigger acute temporary heart failure i.e., (catecholamine (C) cardiomyopathy). Whereas
the normal CO2 levels on Earth are 0.03% in S, during the Euro Mir 94 missions, levels over 10 times higher (0.5-0.7% CO2).
It has been postulated that there is, with S flight, an intracellular shift of calcium (Ca) conducive to vasospasm and damage to
mitochondria. Mg is a Ca blocker and strong antioxidant and is required for thermoregulation with loss of Mg in sweat and
renal Mg loss and dehydration; this will increase potential for heart failure and hypertension. C levels in S are twice supine
levels on Earth. Armstrong, during his last 20 lunar minutes, notified Houston twice during a 4 minute interval that he was
“short of breath” along with heart rates up to 160; tachycardia will intensify oxidative stress in S from Mg ion deficits, high C,
high free fatty acids and vicious cycles. This syndrome has severe dyspnea, severe thirst, severe tachycardia corrected by fluid
replenishment, applies to Earth as well; it would be more likely to occur in post-menopausal women with 90% of cases of C
cardiomyopathy reported in this group, marathoners particularly at the finish line and those in the tropics, particularly with
water shortages. It is likely to be corrected, relatively quickly either by intravenous fluids or a subcutaneous Mg injection.
Keynote Forum
Manuela Stoicescu
University of Oradea, Romania
Keynote: The hidden cardiovascular disease at a patient with pain in the left hypochondrium
Time : 10:10-10:50
Biography:
Manuela Stoicescu, Consultant Internal Medicine Doctor (PhD in Internal Medicine) now is Assistant Professor of Medical Disciplines Department, University of Oradea, Faculty of Medicine and Pharmacy, Romania, Internal Medicine Hospital and Office. She is Member of Romanian Society of Internal Medicine, Member of Romanian Society of Cardiology, Chemistry, Biochemistry and Member of Balcanic Society of Medicine.
Abstract:
The hidden cardiovascular disease at a patient with pain in the left hypochondrium
Objective: The most important objective of this presentation is to found the real cause of a patient with came at the consultation
with sudden pain in the left hypochondrium.
Method: Present the clinical case of a young patient 29 years old, which came at the consultation for sudden onset of pain in the
left hypochondrium, chills and fever 40ºC. At the objective examination BP=120/80 mmHg, HR=100 beats/minute, rhythmic
heart sounds, normal intensity and a systolic murmur heart on the middle of chest, degree III, without irradiation. Auscultation
of the lung was normal vesicular sound. At palpation of the abdomen presented sensibility in the left hypochondrium. The
laboratory tests showed: ESR=60/80 mmHg, fibrinogen=600 mg/dl, leukocytes=16000/mm3, urine examination normal, the
blood culture Staphylococcus aureus positive. The abdominal ultrasound put in evidence unexpected, many small nodules
inside of the parenchyma of the spleen as small cysts and in rest normal. The echocardiography of the heart put in evidence
unexpected an atrial septum defect medium and vegetation of this level. The patient follows antibiotic therapy I.V. and was
referred to as the cardiovascular surgery department.
Result: This patient was in reality with a bacterial endocarditis on an unknown congenital heart disease-atria septum defect and
the small nodules inside of the spleen were microemboli septic in the context of bacterial endocarditis.
Conclusion: This case is interesting because the real cause of the patient with pain in left hypochondrium represented in fact
microemboli in the spleen in the context of endocarditis at a patient with unknown congenital heart disease.
- Clinical Cardiology | Heart Diseases & Heart Failure | Interventional Cardiology | Cardiac & Cardiovascular Research | Clinical Case Reports on Cardiology
Chair
William J Rowe
Medical University of Ohio, USA
Co-Chair
Manuela Stoicescu
University of Oradea, Romania
- Clinical Cardiology | Heart Diseases & Heart Failure | Interventional Cardiology | Cardiac & Cardiovascular Research| Clinical Case Reports on Cardiology
Chair
William J Rowe
Medical University of Ohio, USA
Co-Chair
Manuela Stoicescu
University of Oradea, Romania