Day 2 :
Keynote Forum
Christine Gasperetti
Pennsylvania Hospital, USA
Keynote: The hope of greatly reducing cancer fatality is getting to be realized
Time : 10:00-10:40
Biography:
Christine Gasperetti is an interventional cardiologist with interests in high risk and protected coronary intervention as well as acute myocardial infarction. She has been involved in many studies of coronary artery disease and determinants of platelet function during coronary intervention. She is affiliated with the University of Pennsylvania Health System and works at several of their hospitals and affiliates.
Abstract:
Keynote Forum
Alessandro Delitala
University Hospital of Sassari Italy
Keynote: Beta stiffness index in euthyroid subjects: The role of free thyroxine
Time : 11:00-11:40
Biography:
Dr. Delitala is currently joining the Internal Medicine Unit at Azienda-Ospedaliero- University of Sassari as attending physician. His research focuses on the effect
of subclinical thyroid diseases and their effect on the cardiovascular system. Other area of interest is autoimmune diabetes and factors associated with insulin
dependence.
Abstract:
Beta stiffness index in euthyroid subjects: The role of free thyroxin
Arterial stiffness is an important prognostic factor for cardiovascular mortality in patients with blood hypertension and
in the general population. Recent studies showed that disorders of thyroid gland are associated with an increased aortic
stiffness, although results are not univocal. The effects of free thyroxin on vascular physiology at common carotid level are less
studied. Our study aimed to test the association between free thyroxin and thyrotropin and beta stiffness index at common
carotid level in a cohort of euthyroid patients. This study included 5385 euthyroid patients (2964 women) aged 14-102 years.
Stepwise regression analysis was used to test the association between thyroid hormones and beta stiffness index, the latter
as dependent variable. We found that beta stiffness index had a direct and positive association with free thyroxin level, after
adjusting for the confounder’s age, systolic and diastolic blood pressure, body mass index, triglycerides and smoke. Our results
suggested that higher level of free thyroxin, even in euthyroid subjects, could have a detrimental effect of arterial stiffness at
common carotid level. Further longitudinal studies are required to understand the meaning of this association.
Keynote Forum
Kunlun He
Chinese PLA General Hospital, China
Keynote: Kv4.3 Modulates the distribution of herg
Time : 12:20-13:00
Biography:
Kunlun He is the Vice President of Chinese PLA General Hospital and his main Research Direction is Heart Disease. He has published more than 126 papers in
reputed journals and has been serving as an Editorial Board Member of repute.
Abstract:
Kv4.3 modulates the distribution of hERG
This study examines the interaction between hERG and Kv4.3. The functional interaction between hERG and Kv4.3,
expressed in a heterologous cell line, was studied using patch clamp techniques, western blot, immunofluorescence and
co-immunoprecipitation. Co-expression of Kv4.3 with hERG increased hERG current density (tail current after a step to +10
mV: 26±3 versus 56±7 pA/pF, p<0.01). Kv4.3 co-expression also increased the protein expression and promoted the membrane
localization of hERG. Western blot showed Kv4.3 increased hERG expression by Hsp70. hERG and Kv4.3 co-localized and
co-immunoprecipitated in cultured 293T cells, indicating physical interactions between hERG and Kv4.3 proteins in vitro. In
addition, Hsp70 interacted with hERG and Kv4.3 respectively, and formed complexes with hERG and Kv4.3. The α subunit of
Ito Kv4.3 can interact with and modify the localization of the α subunit of IKr hERG, thus providing potentially novel insights
into the molecular mechanism of the malignant ventricular arrhythmia in heart failure.
Keynote Forum
Danish Abbasi
Atlanti Care Regional Medical Center, USA
Keynote: Rare cRare cardiac manifestation of a commonly prescribed drug: Takotsubo cardiomyopathy caused by allopurinol induced Dress Syndromeardiac manifestation of a commonly prescribed drug: Takotsubo Cardiomyopathy caused by allopurinol induced dress syndrome
Time : 14:00-15:00
Biography:
Danish Abbasi is currently working as a Hospitalist in AtlantiCare Regional Medical Center, NJ. He is involved with Internal Medicine Residency Program and
currently part of Residency Teaching Faculty. He has been appointed as Clinical Assistant Professor (Adjunct) in the Lewis Katz School of Medicine at Temple
University, Department of Medicine. My area of interest is Cardiology and I hope to pursue a cardiology fellowship for 2019.
Abstract:
Takotsubo syndrome from allopurinol has been rarely reported. Our case is unusual presentation of stress induced
cardiomyopathy from allopurinol induced dress syndrome. We present a case of 42-year-old male with history of chronic
kidney disease stage with rash, itching and swelling. Two weeks before he was started on allopurinol for hyperuricemia.
Examination showed swelling of face, extremities with diffuse papular rash. Temperature was 99.3°F, BP 122/93, RR 18.
Blood work showed worsening renal function (Cr 3.10), transaminitis (LDH 184, AST 104, ALT 136) and eosinophilia of
13.6%. RegiSCAR score of 6 was highly suggestive of Dress Syndrome. Patient’s allopurinol was discontinued. Patient was
started on steroids and showed improvement. Patient returned three weeks later with chest pain and shortness of breath. BP
110/68, pulse rate 132, respiratory rate 30 breaths/min, Sat O2 87%.CK-MB 30 and troponin 10. Eosinophil count 19%. EKG
showed sinus tachycardia and diffuse ST elevation. Emergent cardiac catheterization showed no coronary artery disease, severe
LV systolic dysfunction with apical dilation. Ejection fraction was 20% (EF of 55-60%- baseline). Findings were consistent
with Takotsubo Cardiomyopathy (TS). He was continued on steroids and lasix. Skin biopsy showed superficial perivascular
dermatitis. Subendocardial biopsy showed mild perivascular and subendocardial infiltrates not suggestive of active eosinophilic
myocarditis. Patient condition stabilized and EF improved to 45-50%. He was discharged on prednisone taper. DRESS syndrome
is rare, potentially life-threatening hypersensitivity reaction. Early recognition is important as it has associated mortality of
10%. European Registry (RegiSCAR) is the most commonly used diagnostic criteria. Drug induced Takotsubo cardiomyopathy
is mostly associated with medication causing direct or indirect catecholamine stimulation. Although a common association
with Dress Syndrome, allopurinol induced Takotsubo cardiomyopathy is extremely rare. We aim to highlight the importance of
clinical suspicion for takotsubo cardiomyopathy in patients with new onset heart failure treated with allopurinol that remains
a common prescription medication.