Yaping Tian
Yaping Tian, Chinese PLA General Hospital, China
Title: The amino acids profile variation in dried blood spots from patients with acute coronary syndrome
Biography
Biography: Yaping Tian
Abstract
The cardiovascular disease (CVD), which includes acute coronary syndrome (ACS) and heart failure (HF), is the global
leading cause of human death. The blood biomarkers, as targets of treatment, will help to prevent and treat CVD. They
could aid in early prognosis and diagnosis of CVD and effectively reduce the morbidity and mortality, which is the focus in
research for CVD. This study aimed to screen effective blood markers for different stages of CVD. We have detected 11 amino
acids and SA in HC and patients with MS, ACS and HF. GLY and PRO were significant difference between the AMI and the
UAP. The ROC curve area of them in multivariate analysis was 0.681 (0.600-0.754) (p<0.001). ARG, GLY, MET, TYR and SA
were significant difference between the AMI and the MS. The ROC curve area of GLY and ARG in multivariate analysis was
0.953 (0.911-0.979) (p<0.001). There were significant differences in 9 amino acids and SA between the AMI and the HC. The
ROC curve area of GLY, ORN and PHE in multivariate analysis was 0.991 (0.962-0.999) (p<0.001). There were significant
differences in 3 parameters between the CHF and the UAP. The ROC curve area of CIT and L-I-P in multivariate analysis
was 0.839 (0.742-0.910) (p<0.001). Eleven blood amino acids and SA in patients with MS, ACS and CHF and in HC have
been analyzed and the variation between groups have been found, the results suggested that branched chain amino acids and
aromatic amino acids may be biomarkers for CVD.