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Bi-Hua Tan


Bi-Hua Tan

Pennsylvania State University College of Medicine, USA

Biography

Bi-Hua Tan was initially trained as a cardiologist in China after graduated from medical school. Then she joined the arrhythmia and clinical electrophysiological study group at Cardiovascular Division, Hyogo College of Medicine in Japan and obtained her PhD degree there. After that she completed her postdoctoral training at the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin-Madison. She was the first to characterize the molecular phenotype of eight common polymorphisms and some genetic basis of disease causing mutations in cardiac Na channel. She also first characterized a marked gain of functional KATPKir6.1 channel mutation in KCNJ8 as a novel pathogenic mechanism for the phenotypic expression of both Brugada syndrome and early repolarization syndrome. She was awarded American Heart Association (AHA) Postdoctoral Fellowship and the American Heart Association National Center Scientist Development Grant.

Abstract

Abstract : Na channel dysfunction in inherited arrhythmias: the effect of common polymorphism, splice variant and intracellular acidosis